反应条件
1: 89 percent / piperidine / pyridine / 1.) 80 deg C, 1 h, 2.) 100 deg C, 1 h, 3.) heating, 0.5 h 2: 100 percent / hydrogen, Adam's catalyst / 2585.7 Torr 3: thionyl chloride / toluene / 3 h / 55 - 60 °C 4: 1.) aq. sodium azide / 1.) acetone, 0 deg C, 0.5 h, 2.) toluene, 80 deg C, 0.5 h View Scheme
参考文献
Anderson, Wayne K.; Heider, Arvela R.; Raju, Natarajan; Yucht, Jeffery A.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 11 p. 2097 - 2102
