O-((6-(1H-吡唑-1-基)吡啶-3-基)甲基)羟胺合成路线 （共 6 条）
反应条件
ammonia in methanol
T=50°C; 4 h;
参考文献
ENANTA PHARMACEUTICALS, INC.
Patent: WO2005/70918 A1, 2005 ;
Location in patent: Page/Page column 41 ;
反应条件
methanol; hydrazine
T=45°C; 2.5 h;
参考文献
Tang, Datong; Qiu, Yao-Ling; Kim, Heejin; Or, Yat Sun; Wang, Zhe
Patent: US2006/247440 A1, 2006 ;
Location in patent: Page/Page column 15 ;
反应条件
water; sulfuric acid
T=90°C; P=400 Torr; 2 h; Product distribution / selectivity;
参考文献
Shionogi and Co., Ltd.
Patent: WO2006/68102 A1, 2006 ;
Location in patent: Page/Page column 25 ;
反应条件
water; sulfuric acid
T=60°C; P=150 Torr; 2 h; Product distribution / selectivity;
参考文献
Shionogi and Co., Ltd.
Patent: WO2006/68102 A1, 2006 ;
Location in patent: Page/Page column 23-24 ;
反应条件
1.1: diethylene glycol dimethyl ether / 13 h / 115 - 135 °C / Large scale reaction
2.1: sulfuric acid; water / ethanol / 9 h / 70 - 100 °C / 7.5 - 52.51 Torr / Large scale reaction
2.2: 15 - 35 °C / Large scale reaction
View Scheme
参考文献
Shimizu, Sumio; Hakogi, Toshikazu; Umesako, Naomi; Yokota, Yutaka; Ueki, Tatsuo
Organic Process Research and Development, 2012 , vol. 16, # 2 p. 220 - 224
反应条件
1.1: sodium hydroxide / 1-methyl-pyrrolidin-2-one; water / 27 - 40 °C / Inert atmosphere; Large scale reaction
2.1: diethylene glycol dimethyl ether / 13 h / 115 - 135 °C / Large scale reaction
3.1: sulfuric acid; water / ethanol / 9 h / 70 - 100 °C / 7.5 - 52.51 Torr / Large scale reaction
3.2: 15 - 35 °C / Large scale reaction
View Scheme
参考文献
Shimizu, Sumio; Hakogi, Toshikazu; Umesako, Naomi; Yokota, Yutaka; Ueki, Tatsuo
Organic Process Research and Development, 2012 , vol. 16, # 2 p. 220 - 224
