1-甲基-1H-吲哚-4-甲腈合成路线 （共 4 条）
反应条件
potassium carbonate in DMF (N,N-dimethyl-formamide) T=20°C; 48 h;
参考文献
AMGEN INC.
Patent: WO2003/99776 A1, 2003 ;
Location in patent: Page 102 ;
反应条件
sodium hydride in N,N-dimethyl-formamide T=0°C; 0.5 h;
参考文献
WYETH LLC; AYRAL-KALOUSTIAN, Semiramis; MANSOUR, Tarek Suhayl; TSOU, Hwei-Ru; ZHANG, Nan; VENKATESAN, Aranapakam M.; DI, Li; KERNS, Edward H.
Patent: WO2010/30727 A1, 2010 ;
Location in patent: Page/Page column 98 ;
WO 2010/030727 A1
反应条件
cesium fluoride in acetonitrile T=50°C; 16 h; Inert atmosphere;
参考文献
Organic Letters, , vol. 11, # 4 p. 1007 - 1010
反应条件
1: With diisobutylaluminium hydride in dichloromethane; toluene T=-78 - 20°C; 6 h; Nitrogen atmosphere; 2: With sulfuric acid; water in methanol; dichloromethane; toluene
参考文献
AMGEN INC.
Patent: WO2003/99776 A1, 2003 ;
Location in patent: Page 102-103 ;
