4-氨基-3-碘苯甲酸乙酯合成路线 （共 13 条）
反应条件
1: CuI; diethylamine / PdCl2(PPh3)2 / 25 °C 2: potassium carbonate / methanol / 25 °C 3: 98 percent / tris(4-fluorophenyl)phosphine / [Rh(COD)Cl]2 / dimethylformamide / 2 h / 85 °C View Scheme
参考文献
Trost, Barry M.; McClory, Andrew
Angewandte Chemie - International Edition, 2007 , vol. 46, # 12 p. 2074 - 2077
反应条件
1: 98 percent / 10percent aq. KOH / 1 h / Heating 2: 1.) N,N'-carbonyldiimidazole (CDI) / 1.) THF, 1 h, 2.) THF, RT, 8 h 3: 1.) 5percent aq. NaNO2, 8N aq. acetic acid, 2.) 5percent aq NaN3 / 1.) 0 deg C, 4 min, 2.) water, RT, 3 min View Scheme
参考文献
Hirschfeld; Buschauer; Elz; Schunack; Ruat; Traiffort; Schwartz
Journal of Medicinal Chemistry, 1992 , vol. 35, # 12 p. 2231 - 2238
反应条件
1,4-diaza-bicyclo[2.2.2]octane; palladium diacetate in N,N-dimethyl-formamide T=105°C; 16 h; Inert atmosphere;
参考文献
Boucherle, Benjamin; Vogrig, Alexandre; Deokar, Hemantkumar; Bouzidi, Naoual; Ripoche, Isabelle; Thomas, Isabelle; Marin, Philippe; Ducki, Sylvie
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 14 p. 4346 - 4354
反应条件
1: 98 percent / 10percent aq. KOH / 1 h / Heating 2: 1.) N,N'-carbonyldiimidazole (CDI) / 1.) THF, 1 h, 2.) THF, RT, 8 h View Scheme
参考文献
Hirschfeld; Buschauer; Elz; Schunack; Ruat; Traiffort; Schwartz
Journal of Medicinal Chemistry, 1992 , vol. 35, # 12 p. 2231 - 2238
反应条件
potassium hydroxide 1 h; Heating;
参考文献
Hirschfeld; Buschauer; Elz; Schunack; Ruat; Traiffort; Schwartz
Journal of Medicinal Chemistry, 1992 , vol. 35, # 12 p. 2231 - 2238
反应条件
potassium carbonate in N,N-dimethyl-formamide T=40°C; 72 h;
参考文献
Zhou, Jun; Yang, Weijun; Wang, Binjie; Ren, Hongjun
Angewandte Chemie - International Edition, 2012 , vol. 51, # 49 p. 12293 - 12297
Angew. Chem., 2012 , vol. 124, # 49 p. 12459 - 12463,5
反应条件
N,N,N-trimethylbenzenemethanaminium dichloroiodate; calcium carbonate in methanol; dichloromethane
48 h;
参考文献
Hirschfeld; Buschauer; Elz; Schunack; Ruat; Traiffort; Schwartz
Journal of Medicinal Chemistry, 1992 , vol. 35, # 12 p. 2231 - 2238
反应条件
calcium carbonate in methanol; diethyl ether; dichloromethane
参考文献
Wang, Wei-Bo; Curtin, Michael L.; Fakhoury, Stephen A.; Gwaltney II, Stephen L.; Hasvold, Lisa A.; Hutchins, Charles W.; Li, Qun; Lin, Nan-Horng; Nelson, Lissa Taka Jennings; O'Connor, Steve; Sham, Hing L.; Sullivan, Gerard M.; Wang, Gary T.; Wang, Xilu
Patent: US2002/19527 A1, 2002 ;
反应条件
sodium hydrogencarbonate in dichloromethane; water
T=0 - 20°C; 72 h;
参考文献
DuPont Pharmaceuticals Company
Patent: US6342503 B1, 2002 ;
Location in patent: Example 30 ;
US 6342503 B1
参考文献
Frejka; Pirkl
Cesko-Slovenska Farmacie, 1952 , vol. 1, p. 309,312
Chem.Abstr., 1952 , p. 11583
