2,5-二甲氧酰基-1,4-环己二酮合成路线 （共 24 条）
反应条件
1: 1.) NaH / 1.) 1,2-dimethoxyethane, 2.) 1,2-dimethoxyethane, reflux 2: 88.9 percent / BF3*Et2O / acetic acid / 24 h 3: 89.2 percent / EtOH / Raney nickel-W2 / 96 h / Heating 4: 44.9 percent / KOH / methanol; H2O / 24 h View Scheme
参考文献
Nuding; Voegtle; Danielmeier; Steckhan
Synthesis, 1996 , # 1 p. 71 - 76
反应条件
hydrogen; 5 wt. ruthenium on carbon in methanol T=120°C; P=52476.2 - 57647.8 Torr; 16 h;
参考文献
WO2012/125218 A1, ;
Page/Page column 17 ;
反应条件
1: With hydrogen; 5 wt. ruthenium on carbon in methanol T=120°C; P=46787.4 - 47304.6 Torr; 3 h; Inert atmosphere; 2: With sodium acetate in methanol T=200°C; 20 h; Inert atmosphere; Product distribution / selectivity;
参考文献
WO2012/125218 A1, ;
Page/Page column 18-19 ;
反应条件
1: 1.) NaH / 1.) 1,2-dimethoxyethane, 2.) 1,2-dimethoxyethane, reflux 2: 88.9 percent / BF3*Et2O / acetic acid / 24 h 3: 89.2 percent / EtOH / Raney nickel-W2 / 96 h / Heating View Scheme
参考文献
Nuding; Voegtle; Danielmeier; Steckhan
Synthesis, 1996 , # 1 p. 71 - 76
反应条件
1: With toluene-4-sulfonic acid in 2-methyl-propan-1-ol
T=20 - 100°C; 4 h;
2: With sodium hydroxide; water; m-nitrobenzene sulfonic acid sodium salt
4 h; Heating / reflux;
参考文献
MCA TECHNOLOGIES GMBH
Patent: WO2005/85364 A1, 2005 ;
Location in patent: Page/Page column 15 ;
反应条件
1: potassium ethylate; THF; benzene / anschliessendes Erwaermen mit CH3I in Aceton
2: aqueous H2SO4
View Scheme
参考文献
Beyler; Sarett
Journal of the American Chemical Society, 1952 , vol. 74, p. 1397,1399
参考文献
Shimizu, Masaki; Asai, Yuiga; Takeda, Youhei; Yamatani, Akinori; Hiyama, Tamejiro
Tetrahedron Letters, 2011 , vol. 52, # 32 p. 4084 - 4089
反应条件
acetic acid in ethanol
T=120°C; 2 h;
参考文献
Shimizu, Masaki; Asai, Yuiga; Takeda, Youhei; Yamatani, Akinori; Hiyama, Tamejiro
Tetrahedron Letters, 2011 , vol. 52, # 32 p. 4084 - 4089
反应条件
ammonia
T=100°C; im Rohr;
参考文献
Liebermann
Justus Liebigs Annalen der Chemie, 1914 , vol. 404, p. 299
反应条件
T=100°C; im Rohr; reagiert analog mit Anilin;
参考文献
Liebermann
Justus Liebigs Annalen der Chemie, 1914 , vol. 404, p. 299
