反应条件
1: 1) Mg, 2) CuCl2, LiCl / 1) BrCH2CH2Br, THF, a) sonication, 50 deg C, 30 min, b) reflux, 2 h, 2) THF, a) ice/salt bath, 5 h, b) r.t., overnight
2: 37 percent / Li/Na / hexane; tetrahydrofuran / 1.5 h / 50 °C / sonication
3: 87 percent / H2 / 10percent Pd/C / cyclohexane / 15 h / 50 °C / 12001 Torr
4: 81 percent / TsOH*H2O / benzene / 2 h / Heating
5: 95 percent / H2 / 10percent Pd/C / cyclohexane / 15 h / 50 °C / 12001 Torr
View Scheme
参考文献
Dutoit, Jean-Claude
Synthesis, 1992 , # 20 p. 982 - 984
