2-(3-吡啶基)-1-乙醇合成路线 （共 26 条）
反应条件
1: H2SO4 2: aqueous NH3 3: KBrO; aqueous KOH 4: aqueous sulfuric acid; sodium nitrite / 0 °C / und anschliessenden Erwaermen View Scheme
参考文献
Chemische Berichte, , vol. 80, p. 505,507
反应条件
1: KBrO; aqueous KOH 2: aqueous sulfuric acid; sodium nitrite / 0 °C / und anschliessenden Erwaermen View Scheme
参考文献
Chemische Berichte, , vol. 80, p. 505,507
反应条件
1: aqueous NH3 2: KBrO; aqueous KOH 3: aqueous sulfuric acid; sodium nitrite / 0 °C / und anschliessenden Erwaermen View Scheme
参考文献
Chemische Berichte, , vol. 80, p. 505,507
反应条件
1: platinum; H2O / Hydrogenation 2: H2SO4 3: aqueous NH3 4: KBrO; aqueous KOH 5: aqueous sulfuric acid; sodium nitrite / 0 °C / und anschliessenden Erwaermen View Scheme
参考文献
Chemische Berichte, , vol. 80, p. 505,507
反应条件
1: 87 percent / triethylamine / CH2Cl2 / 5 h / Ambient temperature 2: 99 percent / glacial acetic acid, platinum oxide hydrate, hydrogen / ethanol; H2O / 20 h / 2068.6 Torr View Scheme
参考文献
Lowen, Gregory T.; Almond, Merrick R.; Rideout, Janet L.
Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 6 p. 1663 - 1665
反应条件
thionyl chloride in chloroform 15 h; Reflux;
参考文献
GLAXO GROUP LIMITED; WAN, Zehong; ZHANG, XIaomin; WANG, Jian; PENG, Cheng; JIN, Yun; HU, Yimin
Patent: WO2012/75917 A1, 2012 ;
Location in patent: Page/Page column 36-37 ;
WO 2012/075917 A1
参考文献
Bristol-Myers Company
Patent: US4198504 A1, 1980 ;
反应条件
1: 87 percent / triethylamine / CH2Cl2 / 5 h / Ambient temperature 2: 99 percent / glacial acetic acid, platinum oxide hydrate, hydrogen / ethanol; H2O / 20 h / 2068.6 Torr 3: 5percent potassium carbonate / dioxane / 24 h 4: tetrabutylammonium fluoride / tetrahydrofuran / 20 h 5: 90 percent / 4-dimethylaminopyridine, triethylamine / CH2Cl2 6: 99 percent / sodium iodide / acetone / 2 h / Heating 7: 95 percent / 97percent potassium tert-butoxide / tetrahydrofuran View Scheme
参考文献
Lowen, Gregory T.; Almond, Merrick R.; Rideout, Janet L.
Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 6 p. 1663 - 1665
反应条件
1: 100 percent / Et3N / CH2Cl2 / 1.5 h / 20 °C 2: t-BuOK / dimethylsulfoxide / 1 h / 20 °C View Scheme
参考文献
Guandalini, Luca; Dei, Silvia; Manetti, Dina; Romanelli, Maria Novella; Scapecchi, Serena; Teodori, Elisabetta; Varani, Katia
Farmaco (Societa chimica italiana : 1989), 2002 , vol. 57, # 6 p. 487 - 496
反应条件
1: 87 percent / triethylamine / CH2Cl2 / 5 h / Ambient temperature 2: 99 percent / glacial acetic acid, platinum oxide hydrate, hydrogen / ethanol; H2O / 20 h / 2068.6 Torr 3: 5percent potassium carbonate / dioxane / 24 h 4: tetrabutylammonium fluoride / tetrahydrofuran / 20 h View Scheme
参考文献
Lowen, Gregory T.; Almond, Merrick R.; Rideout, Janet L.
Journal of Heterocyclic Chemistry, 1992 , vol. 29, # 6 p. 1663 - 1665
