2-(3-吡啶基)-1-乙醇合成路线 （共 26 条）
反应条件
carbon tetrabromide; triphenylphosphine in tetrahydrofuran T=20°C; 16 h;
参考文献
Boehringer Ingelheim Pharmaceuticals, Inc.
Patent: US2006/25433 A1, 2006 ;
Location in patent: Page/Page column 101 ;
US 20060025433 A1
反应条件
1: mCPBA
2: Me2NCOCl / CH2Cl2
3: methanol
4: CH2Cl2
5: 70 percent / KH / CH2Cl2 / Ambient temperature
6: 1) BF3 * MeOH, 2) NaBH4 / 1) 120 deg C
7: imidazole
8: 1) O3, 2) NaH / 1) methanol, -78 deg C, 2) CH2Cl2, -78 deg C
9: MsCl, Et3N
10: CSA / ethanol
11: Dess-Martin periodinane (DMP)
12: 2) Dess-Martin periodinane (DMP) / 1) irradiation, toluene, -78 deg C
13: 98 percent / methanol
14: Dess-Martin periodinane (DMP)
15: NaClO2, NaH2PO4 / various solvent(s)
17: 1) HCO2H, 2) H2O / 2) 140 deg C
18: 3 N KOH / 120 °C
View Scheme
参考文献
Horikawa, Manabu; Hashimoto, Kimiko; Shirahama, Haruhisa
Tetrahedron Letters, 1993 , vol. 34, # 2 p. 331 - 334
反应条件
tributylphosphine; 1,1'-azodicarbonyl-dipiperidine in tetrahydrofuran
T=20°C;
参考文献
SANOFI-AVENTIS
Patent: US2008/146646 A1, 2008 ;
Location in patent: Page/Page column 9 ;
反应条件
thionyl chloride in chloroform
15 h;
参考文献
Bagley; Thomas; Rudo; Spencer; Doorley; Ossipov; Jerussi; Benvenga; Spaulding
Journal of Medicinal Chemistry, 1991 , vol. 34, # 2 p. 827 - 841
反应条件
ammonium dichromate(VI); calcium chloride
T=60°C; 1.67 h;
参考文献
Shirini; Zolfigol; Safari
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2005 , vol. 44, # 11 p. 2383 - 2386
反应条件
1.1: thionyl chloride / chloroform / 3 h / 20 °C / Inert atmosphere
2.1: ethanol; water / 4 h / Inert atmosphere; Reflux
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 60 °C / Inert atmosphere; Cooling with ice
3.2: Cooling with ice
View Scheme
参考文献
Mitsubishi Chemical Corporation
Patent: EP2390243 A1, 2011 ;
