2-溴-1-[4-羟基-3-(羟基甲基)苯基]-1-乙酮合成路线 （共 7 条）
反应条件
toluene-4-sulfonic acid in dichloromethane T=0°C; 0.666667 h;
参考文献
Procopiou, Panayiotis A.; Morton, Gillian E.; Todd, Martin; Webb, Graham
Tetrahedron Asymmetry, 2001 , vol. 12, # 14 p. 2005 - 2008
反应条件
toluene-4-sulfonic acid in dichloromethane
参考文献
Liu, Juntao; Zhou, Di; Jia, Xian; Huang, Ling; Li, Xingshu; Chan, Albert S.C.
Tetrahedron Asymmetry, 2008 , vol. 19, # 15 p. 1824 - 1828
反应条件
hydrogen bromide in tetrahydrofuran
T=75°C;
参考文献
Bream, Robert N.; Ley, Steven V.; Procopiou, Panayiotis A.
Organic Letters, 2002 , vol. 4, # 22 p. 3793 - 3796
反应条件
sodium tetrahydroborate; acetic acid
T=8 - 20°C;
参考文献
Liu, Anqiu; Huang, Ling; Wang, Zhiren; Luo, Zonghua; Mao, Fei; Shan, Wenjun; Xie, Jiaxing; Lai, Kefang; Li, Xingshu
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 5 p. 1548 - 1552
反应条件
1: polyvinylpyridinium bromide perbromide resin / CH2Cl2
2: 1N HBr / tetrahydrofuran / 75 °C
View Scheme
参考文献
Bream, Robert N.; Ley, Steven V.; Procopiou, Panayiotis A.
Organic Letters, 2002 , vol. 4, # 22 p. 3793 - 3796
反应条件
1.1: resin-bound piperazinomethylpolystyrene / H2O; tetrahydrofuran
1.2: 14 percent / pTSA / toluene / 110 °C
2.1: polyvinylpyridinium bromide perbromide resin / CH2Cl2
3.1: 1N HBr / tetrahydrofuran / 75 °C
View Scheme
参考文献
Bream, Robert N.; Ley, Steven V.; Procopiou, Panayiotis A.
Organic Letters, 2002 , vol. 4, # 22 p. 3793 - 3796
反应条件
1: AlCl3, aluminium chloride / dichloromethane / 15 h / |Reflux
2: sodium tetrahydroborate; acetic acid / 1 h / 10 °C
View Scheme
参考文献
Liu, Anqiu; Huang, Ling; Wang, Zhiren; Luo, Zonghua; Mao, Fei; Shan, Wenjun; Xie, Jiaxing; Lai, Kefang; Li, Xingshu
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 5 p. 1548 - 1552
