(R)-2-甲酰吡咯烷-1-羧酸苯甲酯合成路线 （共 10 条）
反应条件
1: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in tetrahydrofuran T=20°C; 0.5 h; 2: With ammonium hydroxide in tetrahydrofuran T=20°C; 24 h;
参考文献
Cobb, Alexander J. A.; Shaw, David M.; Longbottom, Deborah A.; Gold, Johan B.; Ley, Steven V.
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 1 p. 84 - 96
反应条件
ammonia; triethylamine in methanol T=0°C; Reflux;
参考文献
Diakos, Connie I.; Zhang, Mei; Beale, Philip J.; Fenton, Ronald R.; Hambley, Trevor W.
European Journal of Medicinal Chemistry, 2009 , vol. 44, # 7 p. 2807 - 2814
反应条件
ammonia in N,N-dimethyl-formamide T=0 - 20°C; 16.16 h; Product distribution / selectivity;
参考文献
US2009/93472 A1, ;
Page/Page column 29-30 ;
US 20090093472 A1
反应条件
1: sodium hydroxide / H2O / Ambient temperature 2: 1.) triethylamine, isobutyl chloroformate, 2.) ammonia / 1.) chloroform, 0 deg C, 2 h, 2.) chloroform, RT, overnight View Scheme
参考文献
Journal of Pharmaceutical Sciences, , vol. 80, # 9 p. 837 - 842
反应条件
1: sodium hydroxide / H2O / Ambient temperature 2: 1.) triethylamine, isobutyl chloroformate, 2.) ammonia / 1.) chloroform, 0 deg C, 2 h, 2.) chloroform, RT, overnight View Scheme
参考文献
Journal of Pharmaceutical Sciences, , vol. 80, # 9 p. 837 - 842
反应条件
enzyme-substance from pig's kidney; water Behandeln des Reaktionsprodukts in H20 (pH 8) mit Chlorokohlensaeurebenzylester;
参考文献
Journal of Biological Chemistry, , vol. 193, p. 81,87
反应条件
1: 87.3 percent / hydrogen / 10percent palladium on carbon / methanol / 9 h / Ambient temperature 2: 46.1 percent / lithium aluminum hydride / tetrahydrofuran / 33 h / Heating View Scheme
参考文献
Morikawa; Honda; Endoh -i.; Matsumoto; Akamatsu -i.; Mitsui; Koizumi
Journal of Pharmaceutical Sciences, 1991 , vol. 80, # 9 p. 837 - 842
反应条件
10 palladium on carbon; hydrogen in methanol 7 h;
参考文献
European Journal of Medicinal Chemistry, , vol. 44, # 7 p. 2807 - 2814
反应条件
pyridine; p-toluenesulfonyl chloride in dichloromethane T=20°C; 72 h;
参考文献
Cobb, Alexander J. A.; Shaw, David M.; Longbottom, Deborah A.; Gold, Johan B.; Ley, Steven V.
Organic and Biomolecular Chemistry, 2005 , vol. 3, # 1 p. 84 - 96
反应条件
1: 87.3 percent / hydrogen / 10percent palladium on carbon / methanol / 9 h / Ambient temperature
2: 46.1 percent / lithium aluminum hydride / tetrahydrofuran / 33 h / Heating
View Scheme
参考文献
Morikawa; Honda; Endoh -i.; Matsumoto; Akamatsu -i.; Mitsui; Koizumi
Journal of Pharmaceutical Sciences, 1991 , vol. 80, # 9 p. 837 - 842
