1.1: 1H-imidazole / N,N-dimethyl-formamide / Inert atmosphere 2.1: sulfuric acid / methanol / 4 h / 20 °C / Inert atmosphere 3.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 4 h 4.1: triethylamine; lithium chloride / tetrahydrofuran / 1.5 h / -10 °C / Inert atmosphere 4.2: 2.42 h / -10 °C / Inert atmosphere 5.1: B-chloro-diisopinocampheylborane / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere 6.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 3.5 h / -78 °C / Inert atmosphere 6.2: -78 - 20 °C 7.1: tetrabutyl ammonium fluoride / water; tetrahydrofuran / 4 h / 0 °C 8.1: triethylamine; hydrogen / platinum on carbon / methanol / 24.25 h / 20 °C 9.1: potassium tert-butylate / tetrahydrofuran / 0.75 h / 0 °C / Inert atmosphere 9.2: -15 - -10 °C / Inert atmosphere View Scheme

1.1: 1H-imidazole / N,N-dimethyl-formamide / Inert atmosphere 2.1: sulfuric acid / methanol / 4 h / 20 °C / Inert atmosphere 3.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 4 h 4.1: triethylamine; lithium chloride / tetrahydrofuran / 1.5 h / -10 °C / Inert atmosphere 4.2: 2.42 h / -10 °C / Inert atmosphere 5.1: B-chloro-diisopinocampheylborane / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere 6.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 3.5 h / -78 °C / Inert atmosphere 6.2: -78 - 20 °C 7.1: tetrabutyl ammonium fluoride / water; tetrahydrofuran / 4 h / 0 °C 8.1: triethylamine; hydrogen / platinum on carbon / methanol / 24.25 h / 20 °C View Scheme

1.1: 1H-imidazole / N,N-dimethyl-formamide / Inert atmosphere 2.1: sulfuric acid / methanol / 4 h / 20 °C / Inert atmosphere 3.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 4 h 4.1: triethylamine; lithium chloride / tetrahydrofuran / 1.5 h / -10 °C / Inert atmosphere 4.2: 2.42 h / -10 °C / Inert atmosphere 5.1: B-chloro-diisopinocampheylborane / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere 6.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 3.5 h / -78 °C / Inert atmosphere 6.2: -78 - 20 °C 7.1: tetrabutyl ammonium fluoride / water; tetrahydrofuran / 4 h / 0 °C 8.1: triethylamine; hydrogen / platinum on carbon / methanol / 24.25 h / 20 °C 9.1: potassium tert-butylate / tetrahydrofuran / 0.75 h / 0 °C / Inert atmosphere 9.2: -15 - -10 °C / Inert atmosphere 10.1: caesium carbonate / N,N-dimethyl-formamide / 3 h / 40 °C View Scheme

1: imidazole / dimethylformamide 2: Et2AlCl / CH2Cl2 / 2 h / -50 °C 3: Dess-Martin periodinane; NaHCO3 / CH2Cl2 4: KOtBu / tetrahydrofuran 5: 84 percent / Grubbs' 2nd generation catalyst / CH2Cl2 / 12 h / 40 °C 6: DIBAL-H / CH2Cl2 / -78 °C 7: KOtBu / tetrahydrofuran 8: HCl / tetrahydrofuran / 48 h View Scheme

1: imidazole / dimethylformamide 2: Et2AlCl / CH2Cl2 / 2 h / -50 °C 3: Dess-Martin periodinane; NaHCO3 / CH2Cl2 View Scheme