1: ethyl 3-cyano-2-oxopropionate sodium salt With hydrogenchloride in ethanol; water T=20°C; 0.25 h; 2: N-methoxycarbonyl hydrazine in methanol; water T=20°C; 3: With potassium carbonate in methanol; water T=60°C; 4 h; Heating / reflux;
参考文献
MERZ PHARMA GMBH and CO. KGAA
Patent: US2008/32998 A1, 2008 ;
Location in patent: Page/Page column 20 ;
US 20080032998 A1
1: With toluene-4-sulfonic acid in isopropyl mesylate 24 h; Heating / reflux; 2: With sodium methylate in isopropyl mesylate T=20°C; 72 h; Heating / reflux; 3: With acetic acid in isopropyl mesylate; water pH=5;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2007/18941 A2, 2007 ;
Location in patent: Page/Page column 46 ;
WO 2007/018941 A2
