5,6-二甲氧基茚烷-1-乙酸合成路线 （共 6 条）
反应条件
sodium hydroxide; magnesium in methanol; water
参考文献
Ortho Pharmaceutical Corporation
Patent: US5066658 A1, 1991 ;
US 5066658 A
反应条件
hydrogenchloride; mercury; zinc
Clemmensen's reduction; 8 h; Heating;
参考文献
Sharma, Meenakshi; Ray
European Journal of Medicinal Chemistry, 2008 , vol. 43, # 10 p. 2092 - 2102
反应条件
1: polyphosphoric acid / Heating
2: zinc amalgam, aq. HCl / benzene / Heating
View Scheme
参考文献
Pramanik; Mukherjee
Journal of the Indian Chemical Society, 1997 , vol. 74, # 9 p. 734 - 735
反应条件
1: KOH / ethanol / Heating
2: polyphosphoric acid / Heating
3: zinc amalgam, aq. HCl / benzene / Heating
View Scheme
参考文献
Pramanik; Mukherjee
Journal of the Indian Chemical Society, 1997 , vol. 74, # 9 p. 734 - 735
反应条件
1: piperidine / 72 h / 30 - 40 °C
2: KOH / ethanol / Heating
3: polyphosphoric acid / Heating
4: zinc amalgam, aq. HCl / benzene / Heating
View Scheme
参考文献
Pramanik; Mukherjee
Journal of the Indian Chemical Society, 1997 , vol. 74, # 9 p. 734 - 735
反应条件
1: 90 percent / SOCl2, NH3
2: 72 percent / P2O5 / Heating
3: 59 percent / NaN3, NH4Cl / dimethylformamide / 120 - 150 °C
View Scheme
参考文献
Roy, A.; Gupta, J. K.; Lahiri, S.C.
Journal of the Indian Chemical Society, 1983 , vol. 60, p. 377 - 380
