4-苯基-2,4-二氧丁酸乙酯合成路线 （共 37 条）
反应条件
1: 100 percent / NH2OH*HCl / ethanol / 2 h / Heating 2: 95 percent / LiAlH4 / tetrahydrofuran / 0.5 h / -78 °C 3: 97 percent / Ph3PBr2 / CH2Cl2 / 1 h / Ambient temperature View Scheme
参考文献
Pei; Wickhan
Tetrahedron Letters, 1993 , vol. 34, # 47 p. 7509 - 7512
反应条件
1: 90 percent / Saccharomyces cerevisiae; glucose; phenacyl chloride / aq. phosphate buffer; diisopropyl ether / 48 h / 20 °C / pH 4.5 2: 65 percent / ammonium acetate; sodium cyanoborohydride / ethanol / 36 h / 20 °C View Scheme
参考文献
Fadnavis, Nitin W.; Radhika, Kasiraman R.; Vedamayee Devi
Tetrahedron Asymmetry, 2006 , vol. 17, # 2 p. 240 - 244
反应条件
1: H2NNH2 2: Alkaline hydrolysis View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 17, # 17 p. 4914 - 4919
反应条件
Montmorillonite K10; hydrazine hydrate in isopropyl alcohol Heating;
参考文献
Jagath Reddy; Latha; Srinivasa Rao
Organic Preparations and Procedures International, 2004 , vol. 36, # 5 p. 494 - 498
反应条件
1: 60 percent / AcOH / benzene / Heating 2: NaCNBH3 / acetic acid / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 29, # 32 p. 3997 - 4000
反应条件
ethanol; hydroxylamine hydrochloride Verseifen des entstandenen Aethylesters;
参考文献
Angeli
Chemische Berichte, 1890 , vol. 23, p. 2159
Gazzetta Chimica Italiana, 1890 , vol. 20, p. 769
反应条件
1: 90 percent / Saccharomyces cerevisiae; glucose; phenacyl chloride / aq. phosphate buffer; diisopropyl ether / 48 h / 20 °C / pH 4.5 2: 65 percent / ammonium acetate; sodium cyanoborohydride / ethanol / 36 h / 20 °C 3: 80 percent / aq. NaOH / 4 h / 20 °C 4: 45 percent / penicillin G acylase immobilized on epoxy-resin; phosphate buffer / ethanol; H2O / 1 h / 25 °C / pH 7.5 View Scheme
参考文献
Fadnavis, Nitin W.; Radhika, Kasiraman R.; Vedamayee Devi
Tetrahedron Asymmetry, 2006 , vol. 17, # 2 p. 240 - 244
反应条件
1: NH2OH*HCl / ethanol / 1 h / Heating 2: LiAlH4 / diethyl ether / 0.5 h / 40 °C View Scheme
参考文献
Baraldi, P. G.; Simoni, D.; Moroder, F.; Manfredini, S.; Mucchi, L.; et al.
Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 557 - 560
反应条件
triethylamine in ethanol
1200 h; Ambient temperature;
参考文献
Atfah, Adnan; Hill, John
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1989 , p. 221 - 224
反应条件
1: 2.) NaOH / 1.) water, reflux, 5 min, room temp.,2 h; 2.) water, reflux, 15 min
2: 60 percent / phosphorus pentasulfide / pyridine / 3 h / Heating
3: 1.) sodium methoxide; / 1.) methanol; 2.) room temp., overnight
View Scheme
参考文献
Eid, M. M.; Badawy, M. A.; Ghazala, M. A. H.; Ibrahim, Yehia A.
Journal of Heterocyclic Chemistry, 1983 , vol. 20, p. 1709 - 1711
