chloro-trimethyl-silane; potassium iodide in acetonitrile T=24°C; 6 h;

1: 1) pyridine, trifluoroacetic anhydride / 1) 0 deg C, 15 min, 2) r.t., 60 h 2: 35 percent / sodium acetate, acetic acid, KI / H2O; methanol / 36 h / 37 °C 3: 80 percent / imidazole / dimethylformamide / 24 h / 24 °C 4: 12 mg / KI, trimethylsilyl chloride / acetonitrile / 6 h / 24 °C View Scheme

1: 80 percent / imidazole / dimethylformamide / 24 h / 24 °C 2: 12 mg / KI, trimethylsilyl chloride / acetonitrile / 6 h / 24 °C View Scheme

1: 35 percent / sodium acetate, acetic acid, KI / H2O; methanol / 36 h / 37 °C 2: 80 percent / imidazole / dimethylformamide / 24 h / 24 °C 3: 12 mg / KI, trimethylsilyl chloride / acetonitrile / 6 h / 24 °C View Scheme