(6-氨基-吲哚-3-基)-乙腈合成路线 （共 4 条）
反应条件
hydrogen; palladium 10 on activated carbon in ethanol
T=20°C; P=760.051 Torr; 5 h;
参考文献
Vertex Pharmaceuticals Incorporated
Patent: US2012/309758 A1, 2012 ;
Location in patent: Page/Page column 70 ;
US 20120309758 A1
反应条件
1: pentan-1-ol; sodium acetate; aqueous acetic acid
2: Raney nickel; methanol / Hydrogenation
View Scheme
参考文献
Brown; Garrison
Journal of the American Chemical Society, 1955 , vol. 77, p. 3839,3841
反应条件
1.1: acetic acid / 0.5 h / 0 °C
1.2: 72 h / 20 °C
2.1: methyl iodide / water; tetrahydrofuran / 0.17 h / Reflux
2.2: Reflux
3.1: hydrogen / palladium 10 on activated carbon / ethanol / 5 h / 20 °C / 760.05 Torr
View Scheme
参考文献
Vertex Pharmaceuticals Incorporated
Patent: US2012/309758 A1, 2012 ;
US 20120309758 A1
反应条件
1.1: methyl iodide / water; tetrahydrofuran / 0.17 h / Reflux
1.2: Reflux
2.1: hydrogen / palladium 10 on activated carbon / ethanol / 5 h / 20 °C / 760.05 Torr
View Scheme
参考文献
Vertex Pharmaceuticals Incorporated
Patent: US2012/309758 A1, 2012 ;
US 20120309758 A1
