1: 70 percent / Na, H2O, EtOH / 24 h / Ambient temperature 2: 92 percent / pyridine / acetic anhydride / 3 h / Heating 3: 75 percent / aq. NaOH / benzene / 20 h / Ambient temperature 4: 80 percent / H2SO4 / 24 h / Heating 5: 70 percent / NaBH4 / methanol / 4 h / 0 °C 6: 60 percent / pyridine / 1.) 0 deg C, 1 h, 2.) room temperature, 3 h 7: LiI, HMPA / 150 °C View Scheme

tributylphosphine in acetonitrile T=25°C; Michael Addition; 0.4 h; Inert atmosphere;

1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine in acetonitrile T=64.9°C; 5 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

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sodium ethanolate

1: ethanol 2: alcoholic HCl View Scheme

hydrogenchloride

ethanol; sodium ethanolate 1.) room temperature, 1 h, 2.) 0 deg C (1 h), room temperature (1 h), reflux (2 h); Yield given. Multistep reaction;

sodium ethanolate

hydrogenchloride