反应条件
1: sodium hydroxide / 1,4-dioxane; water / 14 h / 10 - 20 °C 2: lithium chloride / tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 13.5 h / Reflux; Heating 3: sodium hydroxide; ethanol / 1.5 h / 80 °C View Scheme
参考文献
IRONWOOD PHARMACEUTICALS, INC.; HUDSON, Colleen; BARDEN, Timothy, C.; JIA, James; MERMERIAN, Ara; PENG, Bo; YANG, Jane; YU, Xiang, Y.; SPROTT, Kevin
Patent: WO2012/88469 A1, 2012 ;
WO 2012/088469 A1