反应条件
1: 84 percent / pyridine / cyclohexane; dioxane / Ambient temperature 2: 91 percent / xylene / 2 h / Heating 3: 42 percent / sodium hydride / dimethylformamide / 140 °C 4: 1.) NaH / 1.) DMF, 2 h, 2.) DMF, 2 h 5: 89 percent / trifluoroacetic acid / 1.5 h / Ambient temperature 6: 1.) NaH / 1.) DMF, 50 deg C, 1 h, 2.) DMF, 50 deg C, 2 h View Scheme
参考文献
Hargrave, Karl D.; Proudfoot, John R.; Grozinger, Karl G.; Cullen, Ernest; Kapadia, Suresh R.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 7 p. 2231 - 2241
