2-(4-戊炔氧基)四氢-2H-吡喃合成路线 （共 70 条）
反应条件
camphor-10-sulfonic acid in dichloromethane
T=0 - 20°C; 3 h;
参考文献
Hofmann, Tatjana; Altmann, Karl-Heinz
Synlett, 2008 , # 10 p. 1500 - 1504
反应条件
1.1: SOCl2; pyridine
1.2: NaNH2; NH3
2.1: TsOH / CH2Cl2
View Scheme
参考文献
Miura; Okajima; Hondo; Nakagawa; Takahashi; Hosomi
Journal of the American Chemical Society, 2000 , vol. 122, # 46 p. 11348 - 11357
反应条件
in dimethyl sulfoxide
T=5°C;
参考文献
Rossi, Renzo; Carpita, Adriano; Quirici, Maria Grazia
Gazzetta Chimica Italiana, 1981 , vol. 111, # 5/6 p. 173 - 180
反应条件
1: PPTS / CH2Cl2 / 20 °C
2: dimethylsulfoxide / 10 - 20 °C
View Scheme
参考文献
Ettmayer, Peter; Billich, Andreas; Baumruker, Thomas; Mechtcheriakova, Diana; Schmid, Heide; Nussbaumer, Peter
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 6 p. 1555 - 1558
反应条件
potassium fluoride in N,N-dimethyl-formamide
T=55°C; 0.5 h;
参考文献
Stefani, Helio A.; Cardoso, Lincoln D. G.; Valduga, Claudete J.; Zeni, Gilson
Phosphorus, Sulfur and Silicon and Related Elements, 2001 , vol. 171-172, p. 167 - 172
参考文献
Eisai Co., Ltd.
Patent: EP1300464 A1, 2003 ;
反应条件
1: 80 percent / NaNH2 / tetrahydrofuran / 1 h / -60 °C
2: APTS / CH2Cl2 / Ambient temperature
View Scheme
参考文献
Gruiec, Regine; Noiret, Nicolas; Patin, Henri
Bulletin de la Societe Chimique de France, 1994 , vol. 131, # 6 p. 699 - 705
反应条件
ammonia; sodium
Alkylation;
参考文献
Mo, W.-P.; Burger, B. V.; LeRoux, M.; Spies, H. S. C.
Journal of Chemical Ecology, 1995 , vol. 21, # 8 p. 1191 - 1216
反应条件
in dimethyl sulfoxide
T=10 - 20°C;
参考文献
Ettmayer, Peter; Billich, Andreas; Baumruker, Thomas; Mechtcheriakova, Diana; Schmid, Heide; Nussbaumer, Peter
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 6 p. 1555 - 1558
反应条件
1: tetrahydrofuran; hexamethylphosphoric acid triamide / 3 h / 0 - 25 °C
2: KF / dimethylformamide / 0.5 h / 55 °C
View Scheme
参考文献
Stefani, Helio A.; Cardoso, Lincoln D. G.; Valduga, Claudete J.; Zeni, Gilson
Phosphorus, Sulfur and Silicon and Related Elements, 2001 , vol. 171-172, p. 167 - 172
