Rexyn 300 Mixed acid-based ion exchange resin in tetrahydrofuran; water T=40°C; 12 h;

1: 82 percent 2: 90 percent / B(OH)3,H2 / W-2-Raney nickel / H2O; methanol / 1.5 h / 25 °C 3: 41 percent / Rexyn 300 Mixed acid-based ion exchange resin / tetrahydrofuran; H2O / 12 h / 40 °C View Scheme

1: 90 percent / B(OH)3,H2 / W-2-Raney nickel / H2O; methanol / 1.5 h / 25 °C 2: 41 percent / Rexyn 300 Mixed acid-based ion exchange resin / tetrahydrofuran; H2O / 12 h / 40 °C View Scheme

(i) aq. HClO4, dioxane, (ii) K2CO3, PhSH; Multistep reaction;