1: dl-androst-4-ene-3,17-dione With toluene-4-sulfonic acid; orthoformic acid triethyl ester in tetrahydrofuran T=45 - 50°C; 2: formaldehyd With N-methylaniline in tetrahydrofuran; water T=45 - 50°C; 3 h; Product distribution / selectivity;
1: 86 percent / CsF / dimethylformamide / 6 h / 150 °C
2: (C7H15)N(1+)Cl(1-), D2O, NaOD / toluene / 60 °C
3: NaBD4 / ethanol-d1; H2O / 20 °C
4: 93 percent / aq H2SO4 / tetrahydrofuran / 60 °C
View Scheme
参考文献
Jarman, Michael; McCague, Raymond
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1987 , p. 1129 - 1134
