1: With lithium carbonate in water; tert-butyl alcohol T=23°C; 0.166667 h; Resolution of racemate; 2: With 2-hydroxymethyl-pyridine; Alcalase; water; Zn(CH3COO)2*2H2O in tert-butyl alcohol T=23°C; 4 h; Resolution of racemateEnzymatic reaction; optical yield given as percent ee;
参考文献
Felten, Albert E.; Zhu, Gangguo; Aron, Zachary D.
Organic Letters, 2010 , vol. 12, # 9 p. 1916 - 1919
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), , vol. 35, # 10 p. 2142 - 2144
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, , # 10 p. 2340 - 2342
(R)-15-aminomethyl-14-hydroxy-5,5-dimethyl-2,8-dithiolt;9gt;(2,5)pyridinophane; zinc diacetate; sodium methylate in methanol T=25°C; 24 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 63, # 7 p. 1925 - 1928
