反应条件
1: 80.5 percent / NaOH / methanol / 6 h / Heating 2: 77.4 percent / NEt3, dicyclohexylcarbodiimide (DCC) / dimethylformamide; CH2Cl2 / 1.) -20 deg C, overnight, 2.) RT, 4 h 3: ammonium formate, Pd(OAc)2 / 10percent Pd/C / ethyl acetate; methanol / 6 h / Ambient temperature 4: dicyclohexylcarbodiimide (DCC) / ethyl acetate / 1.) -20 deg C, overnight, 2.) RT, 4 h 5: ammonium formate, Pd(OAc)2 / 10percent Pd/C / ethanol; dimethylformamide / 7 h / Ambient temperature 6: dicyclohexylcarbodiimide (DCC) / ethyl acetate; dimethylformamide / 1.) -5 deg C, overnight, 2.) RT, 4 h 7: ammonium formate, Pd(OAc)2 / 10percent Pd/C / methanol; dimethylformamide / 7 h / Ambient temperature 8: dicyclohexylcarbodiimide (DCC) / ethyl acetate; dimethylformamide / 1.) -5 deg C, overnight, 2.) RT, 4 h 9: 71 percent / anisole, TFA / CH2Cl2 View Scheme
参考文献
Carpino, Louis A.; Chao, Hann Guang; Tien, Jien-Heh
Journal of Organic Chemistry, 1989 , vol. 54, # 18 p. 4302 - 4313
