反应条件
1: 53 percent / conc. H2SO4, conc. HNO3 / 0.5 h / Ambient temperature
2: 76 percent / SOCl2 / 4 h / -10 - 40 °C
3: 65 percent / NaBH4 / ethanol; H2O / 4 h / Heating
4: 75 percent / 0.2M aq. KOH / toluene / 2 h / 0 - 20 °C
5: 79 percent / H2, aq. HCl / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature
6: conc. aq. HCl, NaNO2 / 0.5 h / 0 °C
7: 1.) aq. KOH, 3.) aq. HCl
8: polyphosphoric ester / CHCl3 / 8 h / Heating
View Scheme
参考文献
Moloney, Gerard P.; Robertson, Alan D.; Martin, Graeme R.; MacLennan, Steven; Mathews, Neil; Dodsworth, Susan; Sang, Pang Yih; Knight, Cameron; Glen, Robert
Journal of Medicinal Chemistry, 1997 , vol. 40, # 15 p. 2347 - 2362