反应条件
1: 1 N NaOH / dioxane / 1.) 0 deg C, 2 h, 2.) RT, 10 h
2: trifluoroacetic acid TFA / CH2Cl2 / 1 h / 0 °C
3: 75 percent / 1 N NaOH / dioxane / 1.) 0 deg C, 2 h, 2.) RT, 10 h
4: N-methylmorpholine NMM, N,N'-dicyclohexylcarbodiimide DCC, HOBt / dimethylformamide / 1.) 0 deg C, 2 h, 2.) RT, 24 h
5: trifluoroacetic acid TFA / CH2Cl2 / 1 h / 0 °C
View Scheme
参考文献
Lazarus, LH; Salvadori, S; Grieco, P; Wilson, WE; Tomatis, R
European Journal of Medicinal Chemistry, 1992 , vol. 27, # 8 p. 791 - 797
