1: 95 percent / DIEA / dioxane / 0.5 h / 0 °C
2: 79 percent / Bf3*Et2O / CH2Cl2; cyclohexane / 96 h / 25 °C
View Scheme
参考文献
Jensen, Knud J.; Alsina, Jordi; Songster, Michael F.; Vagner, Josef; Albericio, Fernando; Barany, George
Journal of the American Chemical Society, 1998 , vol. 120, # 22 p. 5441 - 5452
1: (S)-2-[(tert-butoxy)carbonylamino]-3-(benzyloxycarbonyl)propanoic acid With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide in tetrahydrofuran
Inert atmosphereCooling;
2: L-phenylalanine With 4-methyl-morpholine in tetrahydrofuran
Inert atmosphereCooling;