1-溴-2,2-二甲基丙烷合成路线 （共 70 条）
反应条件
1: (i) Mg, ether, (ii) /BRN= 605384/, (iii) aq. H2SO4
2: H2O, Me2NH*HCl / 24 h / 70 °C
View Scheme
参考文献
Fujii; Hiraga; Yoshifuji; et al.
Chemical and Pharmaceutical Bulletin, 1978 , vol. 26, # 10 p. 3233 - 3237
反应条件
in tetrahydrofuran
0°C in N2-atmosphere; various yields for various conditions;
参考文献
Smith, Gary F.; Kuivila, Henry G.; Simon, Reyna; Sultan, Leslie
Journal of the American Chemical Society, 1981 , vol. 103, # 4 p. 833 - 839
反应条件
sodium in ammonia
(N2); (CH3)3SnCl and Na added to liquid NH3 and stirred vigorously for 1 h; propane added dropwise and stirred for 1 h; evapd.; dissolved in moist ether; titrated with I2 in ether; washed with a soln. of Na2S2O5; dried; evapd.; distd.;
参考文献
Hawker, Darryl W.; Wells, Peter R.
Organometallics, 1985 , vol. 4, p. 821 - 825
反应条件
also in the presence of dicyclohexylphospin (DCPH); Product distribution;
参考文献
Kuivila, Henry G.; Smith, Gary F.
Journal of Organic Chemistry, 1980 , vol. 45, # 14 p. 2918 - 2919
反应条件
in tetrahydrofuran
T=25°C; 2 h;
参考文献
Bright, Danielle Angrand; Mathisen, Donald E.; Zieger, Herman E.
Journal of Organic Chemistry, 1982 , vol. 47, # 18 p. 3521 - 3524
反应条件
fluoride in gas
reaction efficiency, ΔH0Rx; Rate constantThermodynamic data;
参考文献
DePuy, Charles H.; Gronert, Scott; Mullin, Amy; Bierbaum, Veronica M.
Journal of the American Chemical Society, 1990 , vol. 112, # 24 p. 8650 - 8655
反应条件
hydrogen iodide; tri-n-butylhexadecylphosphonium bromide
T=105°C; 60 h;
参考文献
Landini, Dario; Albanese, Domenico; Mottadelli, Sabrina; Penso, Michele
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 18 p. 2309 - 2312
反应条件
lithium triethylborohydride in tetrahydrofuran
T=65°C; 3 h; var. time, var. temp.; Rate constantProduct distribution;
参考文献
Krishnamurthy, S.; Brown, Herbert C.
Journal of Organic Chemistry, 1983 , vol. 48, # 18 p. 3085 - 3091
反应条件
also in the presence of dicyclohexylphospin (DCPH); Product distribution;
参考文献
Kuivila, Henry G.; Smith, Gary F.
Journal of Organic Chemistry, 1980 , vol. 45, # 14 p. 2918 - 2919
反应条件
sodium hydroxide in 1,2,4-trimethylcyclohexane, cis-trans; water; 2-methyl cyclohexane
T=20 - 160°C; 134 h; Heating / reflux;
参考文献
Sankyo Agro Company, Limited
Patent: EP1580189 A1, 2005 ;
Location in patent: Page/Page column 32 ;
