6-氧代-1,6-二氢哒嗪-3-甲酸甲酯合成路线 （共 5 条）
反应条件
pyridine; manganese(IV) oxide in toluene T=65°C; 6 h;
参考文献
THE SCRIPPS RESEARCH INSTITUTE; BOGER, Dale, L.
Patent: WO2010/5572 A2, 2010 ;
Location in patent: Page/Page column 85 ;
WO 2010/005572 A2
反应条件
thionyl chloride 16 h; Heating / reflux;
参考文献
XENON PHARMACEUTICALS INC.
Patent: WO2006/34440 A2, 2006 ;
Location in patent: Page/Page column 43 ;
WO 2006/034440 A2
参考文献
US2014/100231 A1, ;
Page/Page column ;
反应条件
trichlorophosphate 2.5 h; Heating / reflux;
参考文献
XENON PHARMACEUTICALS INC.
Patent: WO2006/34440 A2, 2006 ;
Location in patent: Page/Page column 43 ;
WO 2006/034440 A2
反应条件
1: sodium methylate; methanol 2: NaOH; water View Scheme
参考文献
Teotino; Cignarella
Gazzetta Chimica Italiana, 1959 , vol. 89, p. 1200,1204, 1206
