3-羟甲基-1,2,3,4-四氢异喹啉合成路线 (共 14 条)
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 3.5 h; Inert atmosphere;
参考文献
Chelopo, Madichaba P.; Pawar, Sachin A.; Sokhela, Mxolisi K.; Govender, Thavendran; Kruger, Hendrik G.; Maguire, Glenn E. M.
European Journal of Medicinal Chemistry, 2013 , vol. 66, p. 407 - 414
反应条件
sodium hydroxide; boron trifluoride in tetrahydrofuran; methanol
参考文献
Astra AB
Patent: US6034097 A1, 2000 ;
US 6034097 A
反应条件
dimethylsulfide borane complex; boron trifluoride diethyl etherate in tetrahydrofuran Reduction; 6 h; Heating;
参考文献
Aggarwal, Varinder K.; Humphries, Paul S.; Fenwick, Ashley
Journal of the Chemical Society - Perkin Transactions 1, 1999 , # 20 p. 2883 - 2889
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 0 deg C, 1 h; 60 deg C, 16 h;
参考文献
Liu, Lee Tai; Lin, Ya-Chuan; Wang, Chia-Lin J.; Lin, Mei-Shey; Yen, Su-Chen; Chen, Hsiao-Jen
Bioorganic and Medicinal Chemistry Letters, 1996 , vol. 6, # 12 p. 1335 - 1338
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
参考文献
Kang, Chuanqing; Bian, Zheng; He, Yabing; Han, Fushe; Qiu, Xuepeng; Gao, Lianxun
Chemical Communications, 2011 , vol. 47, # 38 p. 10746 - 10748
反应条件
1: 66 percent / conc. HCl / 85 °C 2: 86 percent / LiAlH4 / tetrahydrofuran / 6 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 63, # 22 p. 7795 - 7804
反应条件
lithium aluminium tetrahydride in tetrahydrofuran Heating;
参考文献
Tetrahedron Asymmetry, , vol. 3, # 2 p. 223 - 226
反应条件
Yield given. Multistep reaction;
参考文献
Tetrahedron Letters, , vol. 28, # 35 p. 4065 - 4068
反应条件
1: 96 percent / triethylamine / CH2Cl2 2: 87 percent / triethylamine; SO3*pyridine; DMSO / CH2Cl2 / 1 h / 0 °C View Scheme
参考文献
Molander, Gary A.; Romero, Jan Antoinette C.
Tetrahedron, 2005 , vol. 61, # 10 p. 2631 - 2643
反应条件
triethylamine in tetrahydrofuran 3 h;
参考文献
SK Corporation
Patent: EP1149079 B1, 2004 ;
Location in patent: Page 16-17 ;