5-(苄氧基)-2-溴吡啶合成路线 （共 14 条）
反应条件
1.1: tris-(dibenzylideneacetone)dipalladium(0); sodium t-butanolate; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl / toluene / 4.5 h / 100 °C / |Inert atmosphere; |Schlenk technique
2.1: trifluoroacetic acid / dichloromethane / 20 °C
2.2: pH 10
View Scheme
参考文献
Partridge, Benjamin M.; Hartwig, John F.
Organic Letters, 2013 , vol. 15, # 1 p. 140 - 143
反应条件
n-butyllithium in tetrahydrofuran; toluene
T=-60°C; 1 h; Inert atmosphere;
参考文献
SANOFI; SCHWINK, Lothar; BOSSART, Martin; GLOMBIK, Heiner; GOSSEL, Matthias; KADEREIT, Dieter; KLABUNDE, Thomas; MAIER, Thomas; STENGELIN, Siegfried
Patent: WO2014/56938 A1, 2014 ;
Location in patent: Page/Page column 68 ;
反应条件
1: toluene / 66 h / Reflux; Inert atmosphere
2: sodium tetrahydroborate / Inert atmosphere
View Scheme
参考文献
Serban, Georgeta; Abe, Hitoshi; Takeuchi, Yasuo
Heterocycles, 2011 , vol. 83, # 9 p. 1989 - 2000
反应条件
1: 2-bromo-5-benzyloxypyridine With n-butyllithium in hexane; toluene
T=-78°C; 0.95 h;
2: N,N-dimethyl-formamide in hexane; toluene
T=-78°C; 1 h;
3: With water in hexane; toluene
T=-10 - 20°C; 2 h;
参考文献
JAPAN TOBACCO INC.
Patent: US2011/77267 A1, 2011 ;
Location in patent: Page/Page column 46 ;
US 20110077267 A1
