3-(吡啶-2-基)哌啶-1-羧酸叔丁酯合成路线 （共 3 条）
反应条件
1.1: lithium diisopropylamide / tetrahydrofuran; hexane / 0.25 h / -78 °C
1.2: 24 percent / tetrahydrofuran; hexane / -78 - 20 °C
2.1: Pd(PPh3)4 / tetrahydrofuran / Heating
3.1: H2 / Pd-C / methanol / 20 °C
View Scheme
参考文献
Wang, Xueqing; Bhatia, Pramila A.; Daanen, Jerome F.; Latsaw, Steve P.; Rohde, Jeffrey; Kolasa, Teodozyi; Hakeem, Ahmed A.; Matulenko, Mark A.; Nakane, Masaki; Uchic, Marie E.; Miller, Loan N.; Chang, Renjie; Moreland, Robert B.; Brioni, Jorge D.; Stewart, Andrew O.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 15 p. 4667 - 4678
反应条件
1: Pd(PPh3)4 / tetrahydrofuran / Heating
2: H2 / Pd-C / methanol / 20 °C
View Scheme
参考文献
Wang, Xueqing; Bhatia, Pramila A.; Daanen, Jerome F.; Latsaw, Steve P.; Rohde, Jeffrey; Kolasa, Teodozyi; Hakeem, Ahmed A.; Matulenko, Mark A.; Nakane, Masaki; Uchic, Marie E.; Miller, Loan N.; Chang, Renjie; Moreland, Robert B.; Brioni, Jorge D.; Stewart, Andrew O.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 15 p. 4667 - 4678
反应条件
trifluoroacetic acid in dichloromethane
参考文献
Wang, Xueqing; Bhatia, Pramila A.; Daanen, Jerome F.; Latsaw, Steve P.; Rohde, Jeffrey; Kolasa, Teodozyi; Hakeem, Ahmed A.; Matulenko, Mark A.; Nakane, Masaki; Uchic, Marie E.; Miller, Loan N.; Chang, Renjie; Moreland, Robert B.; Brioni, Jorge D.; Stewart, Andrew O.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 15 p. 4667 - 4678
