4-{[2-(三氟甲基)吡啶-4-基]氧基}苯胺合成路线 （共 3 条）
反应条件
1: 4-amino-phenol With potassium tert-butylate in N,N-dimethyl acetamide
T=-5 - 20°C;
2: 4-fluoro-2-trifluoromethyl-pyridine in N,N-dimethyl acetamide
T=25°C; 18 h;
参考文献
BAYER PHARMACEUTICALS CORPORATION
Patent: WO2005/35507 A2, 2005 ;
Location in patent: Page/Page column 65 ;
WO 2005/035507 A2
反应条件
1: 4-amino-phenol With potassium tert-butylate in isobutyramide
T=-5 - 20°C;
2: 4-fluoro-2-trifluoromethyl-pyridine in isobutyramide
T=25°C; 18 h;
参考文献
BAYER PHARMACEUTICALS CORPORATION
Patent: WO2006/99231 A1, 2006 ;
Location in patent: Page/Page column 50 ;
反应条件
hydrogen; nickel in methanol; ethanol
T=20°C; 24 h;
参考文献
NOVARTIS AG; NOVARTIS PHARMA GMBH
Patent: WO2003/99771 A2, 2003 ;
Location in patent: Page 112, 113 ;
WO 03/099771 A2
