1-环己基-2,2,2-三氟-乙酮合成路线 （共 14 条）
反应条件
1: 62 percent Spectr. / Mg / dimethylformamide / 0.5 h / 0 °C 2: TiCl4 / CH2Cl2 / -78 °C View Scheme
参考文献
Amii, Hideki; Kobayashi, Takeshi; Hatamoto, Yasushi; Uneyama, Kenji
Chemical Communications, 1999 , # 14 p. 1323 - 1324
反应条件
Dess-Martin periodane in dichloromethane
3 h; Ambient temperature;
参考文献
Linderman, Russell J.; Graves, David M.
Journal of Organic Chemistry, 1989 , vol. 54, # 3 p. 661 - 668
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran; pentane
48 h; Ambient temperature;
参考文献
Wiedemann, Juergen; Heiner, Thomas; Mloston, Gregorz; Prakash, G.K. Surya; Olah, George A.
Angewandte Chemie - International Edition, 1998 , vol. 37, # 6 p. 820 - 821
反应条件
in diethyl ether
T=-78 - 20°C;
参考文献
Creary, Xavier
Journal of Organic Chemistry, 1987 , vol. 52, # 22 p. 5026 - 5030
反应条件
Co(III) ortho-phenylene-bis(N'-methyloxamidate); oxygen; pivalaldehyde in dichloromethane
参考文献
Blay, Gonzalo; Fernandez, Isabel; Marco-Aleixandre, Alicia; Monje, Belen; Pedro, Jose R; Ruiz, Rafael
Tetrahedron, 2002 , vol. 58, # 42 p. 8565 - 8571
反应条件
in diethyl ether
1 h; Heating;
参考文献
Ramachandran, P. Veeraraghavan; Teodorovic, Aleksandar V.; Brown, Herbert C.
Tetrahedron, 1993 , vol. 49, # 9 p. 1725 - 1738
反应条件
1: 1-bromocyclohexane With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; 2 h;
2: N-(trifluoroacetyl)piperidine in tetrahydrofuran; hexane
T=-78 - 20°C; 3 h;
参考文献
Dong, Kaiwu; Li, Yang; Wang, Zheng; Ding, Kuiling
Angewandte Chemie - International Edition, 2013 , vol. 52, # 52 p. 14191 - 14195
Angew. Chem., 2013 , vol. 125, # 52 p. 14441 - 14445,5
反应条件
1: 65 percent / tetrahydrofuran / 1 h / -78 °C
2: 98 percent / KOH / ethanol / 20 °C
3: 82 percent / Co(III) o-phenylene-bis(N'-methyloxamidate) complex; O2; pivalaldehyde / CH2Cl2
View Scheme
参考文献
Blay, Gonzalo; Fernandez, Isabel; Marco-Aleixandre, Alicia; Monje, Belen; Pedro, Jose R; Ruiz, Rafael
Tetrahedron, 2002 , vol. 58, # 42 p. 8565 - 8571
反应条件
1: 98 percent / KOH / ethanol / 20 °C
2: 82 percent / Co(III) o-phenylene-bis(N'-methyloxamidate) complex; O2; pivalaldehyde / CH2Cl2
View Scheme
参考文献
Blay, Gonzalo; Fernandez, Isabel; Marco-Aleixandre, Alicia; Monje, Belen; Pedro, Jose R; Ruiz, Rafael
Tetrahedron, 2002 , vol. 58, # 42 p. 8565 - 8571
反应条件
in diethyl ether
Heating;
参考文献
Herkes,F.E.; Burton,D.J.
Journal of Organic Chemistry, 1967 , vol. 32, p. 1311 - 1318
