反应条件
1.1: LDA / tetrahydrofuran / -78 - 20 °C
1.2: 52 percent / tetrahydrofuran / -78 - 20 °C
2.1: 47 percent / K2CO3 / acetone / 2 h / Heating
3.1: 40 percent / ethane-1,2-diol / 72 h / 100 - 125 °C
View Scheme
参考文献
Hollick, Jonathan J.; Rigoreau, Laurent J. M.; Cano-Soumillac, Celine; Cockcroft, Xiaoling; Curtin, Nicola J.; Frigerio, Mark; Golding, Bernard T.; Guiard, Sophie; Hardcastle, Ian R.; Hickson, Ian; Hummersone, Marc G.; Menear, Keith A.; Martin, Niall M. B.; Matthews, Ian; Newell, David R.; Ord, Rachel; Richardson, Caroline J.; Smith, Graeme C. M.; Griffin, Roger J.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 8 p. 1958 - 1972