1-((E)-2-溴乙烯基)-4-甲氧基苯合成路线 （共 17 条）
反应条件
1: cis-1-bromo-2-(p-methoxyphenyl)ethylene With tert.-butyl lithium in tetrahydrofuran; hexane
T=-78°C; 1 h;
2: methyl iodide in tetrahydrofuran; hexane
T=-78 - 20°C; Further stages.;
参考文献
Vassilikogiannakis; Hatzimarinaki; Orfanopoulos
Journal of Organic Chemistry, 2000 , vol. 65, # 24 p. 8180 - 8187
反应条件
1: With 1,8-diazabicyclo[5.4.0]undec-7-ene in N,N-dimethyl-formamide
0.0333333 h; Microwave irradiation;
2: With copper(l) iodide in N,N-dimethyl-formamide
T=20°C; 8 h;
参考文献
Zhang, Wen-Sheng; Xu, Wen-Jing; Zhang, Fei; Qu, Gui-Rong
Chinese Chemical Letters, 2013 , vol. 24, # 5 p. 407 - 410
反应条件
copper(l) iodide; bis(4-methylbenzoyl) disulfide in N,N,N',N',N'',N''-hexamethylphosphoric triamide
参考文献
Ogawa, Takuji; Hotta, Shunsuke; Hayami, Kazuo; Suzuki, Hitomi
Chemistry Letters, 1992 , # 10 p. 1947 - 1950
反应条件
palladium diacetate; triethylamine; 1,4-di(diphenylphosphino)-butane in dimethyl sulfoxide
T=115°C; Heck vinylation; 0.5 h; Inert atmosphere; regioselective reaction;
参考文献
McConville, Matthew; Saidi, Ourida; Blacker, John; Xiao, Jianliang
Journal of Organic Chemistry, 2009 , vol. 74, # 7 p. 2692 - 2698
反应条件
copper(I) oxide; water; caesium carbonate; 1-n-butyl-3-methylimidazolium hexafluorophosphate; sodium hydroxide; N-methyl-2-(methylamino)ethylamine
T=100°C; 12 h; Inert atmosphereSealed tube;
参考文献
Wang, Jichao; Yin, Xinchi; Wu, Jun; Wu, Datong; Pan, Yuanjiang
Tetrahedron, 2013 , vol. 69, # 48 p. 10463 - 10469
反应条件
copper(l) iodide; potassium carbonate; N-methyl-2-(methylamino)ethylamine in tetrahydrofuran
T=80°C; 18 h; Inert atmosphere;
参考文献
Cheung, Chi Wai; Buchwald, Stephen L.
Journal of Organic Chemistry, 2012 , vol. 77, # 17 p. 7526 - 7537
反应条件
1: potassium carbonate; copper(l) iodide; N-methyl-2-(methylamino)ethylamine / tetrahydrofuran / 18 h / 80 °C / |Inert atmosphere
2: copper(ll) bromide; tetrabutylammomium bromide; dipotassium peroxodisulfate; 3-pyridinecarboxylic acid ethyl ester / acetonitrile / 24 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
Cheung, Chi Wai; Buchwald, Stephen L.
Journal of Organic Chemistry, 2012 , vol. 77, # 17 p. 7526 - 7537
