(2S)-2-氨基-3,3-二甲基丁酸甲酯合成路线 （共 25 条）
反应条件
3: Heating 5: 1) BuLi / 1) THF, -78 deg C; 2) THF 6: 0.25N aq. HCl / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 39, # 12 p. 2085 - 2092
反应条件
trifluoroacetic acid in tetrahydrofuran 4 h; Ambient temperature;
参考文献
Groth, Ulrich; Halfbrodt, Wolfgang; Schoellkopf, Ulrich
Liebigs Annalen der Chemie, 1992 , # 4 p. 351 - 356
反应条件
1: 77 percent / conc. sulfuric acid / 48 h / Ambient temperature 2: 96 percent / H2 / 10percent Pd/C / aq. ethanol / 2280 Torr 3: 76 percent / conc. HCl / 100 °C 4: 52 percent / HCl gas / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 54, # 5 p. 1055 - 1062
反应条件
1: 96 percent / H2 / 10percent Pd/C / aq. ethanol / 2280 Torr 2: 76 percent / conc. HCl / 100 °C 3: 52 percent / HCl gas / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 54, # 5 p. 1055 - 1062
反应条件
1: 82 percent / methanol / 20 h / Ambient temperature 2: 77 percent / conc. sulfuric acid / 48 h / Ambient temperature 3: 96 percent / H2 / 10percent Pd/C / aq. ethanol / 2280 Torr 4: 76 percent / conc. HCl / 100 °C 5: 52 percent / HCl gas / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 54, # 5 p. 1055 - 1062
反应条件
hydrogen; palladium on activated charcoal in methanol
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 16 p. 2715 - 2718
反应条件
1: CH2Cl2 2: H2 / Pd/C / methanol View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 16 p. 2715 - 2718
反应条件
2: 1) BuLi / 1) THF, -78 deg C; 2) THF 3: 0.25N aq. HCl / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 39, # 12 p. 2085 - 2092
反应条件
1: Heating 3: 1) BuLi / 1) THF, -78 deg C; 2) THF 4: 0.25N aq. HCl / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 39, # 12 p. 2085 - 2092
反应条件
2: Heating 4: 1) BuLi / 1) THF, -78 deg C; 2) THF 5: 0.25N aq. HCl / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 39, # 12 p. 2085 - 2092
