(2S)-2-氨基-3,3-二甲基丁酸甲酯合成路线 （共 25 条）
反应条件
1: 1) n-BuLi / 1) hexane, THF, -70 deg C, 15 min, 2) 4 h 2: 62 percent / n-BuLi / tetrahydrofuran; hexane / 6 h / -70 °C 3: 99 percent / potassium azodicarboxylate, AcOH / methanol / 1 h / Ambient temperature 4: 0.1 N TFA / tetrahydrofuran / 4 h / Ambient temperature View Scheme
参考文献
Liebigs Annalen der Chemie, , # 4 p. 351 - 356
反应条件
hydrogenchloride Heating;
参考文献
Speelman, Johanna C.; Talma, Auke G.; Kellogg, Richard M.; Meetsma, A.; Boer, J. L. de; et al.
Journal of Organic Chemistry, 1989 , vol. 54, # 5 p. 1055 - 1062
反应条件
1: 99 percent / potassium azodicarboxylate, AcOH / methanol / 1 h / Ambient temperature 2: 0.1 N TFA / tetrahydrofuran / 4 h / Ambient temperature View Scheme
参考文献
Liebigs Annalen der Chemie, , # 4 p. 351 - 356
反应条件
1: 62 percent / n-BuLi / tetrahydrofuran; hexane / 6 h / -70 °C 2: 99 percent / potassium azodicarboxylate, AcOH / methanol / 1 h / Ambient temperature 3: 0.1 N TFA / tetrahydrofuran / 4 h / Ambient temperature View Scheme
参考文献
Liebigs Annalen der Chemie, , # 4 p. 351 - 356
反应条件
1: 76 percent / conc. HCl / 100 °C 2: 52 percent / HCl gas / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 54, # 5 p. 1055 - 1062
反应条件
hydrogenchloride; ammonium hydroxide 1.) room temp., 12 h, 2.) H2O, ether, pH=8-10; Yield given. Multistep reaction. Title compound not separated from byproducts;
参考文献
Synthesis, , # 10 p. 861 - 864
反应条件
hydrogenchloride; ammonium hydroxide 1.) room temp., 3 h, 2.) H2O, ether, pH=8-10; Yield given. Multistep reaction;
参考文献
Synthesis, , # 10 p. 861 - 864
反应条件
hydrogenchloride; ammonium hydroxide 1.) room temp., 48 h, 2.) H2O, ether, pH=8-10; Yield given. Multistep reaction;
参考文献
Synthesis, , # 10 p. 861 - 864
反应条件
hydrogenchloride; ammonium hydroxide 1.) room temp., 20 h, 2.) H2O, ether, pH=8-10; Yield given. Multistep reaction;
参考文献
Schoellkopf, Ulrich; Neubauer, Hans-Juergen
Synthesis, 1982 , # 10 p. 861 - 864
反应条件
hydrogenchloride; ammonium hydroxide 1.) room temp., 6 h, 2.) H2O, ether, pH=8-10; Yield given. Multistep reaction;
参考文献
Schoellkopf, Ulrich; Neubauer, Hans-Juergen
Synthesis, 1982 , # 10 p. 861 - 864
