1-(4-碘苯基)-环丙胺合成路线 (共 2 条)
反应条件
trifluoroacetic acid in dichloromethane
T=20°C; 2 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2003/99276 A1, 2003 ;
Location in patent: Page 386 ;
WO 03/099276 A1
反应条件
1: With titanium(IV) isopropylate in diethyl ether
T=-65 - 20°C; 1 h;
2: With boron trifluoride diethyl etherate in diethyl ether
T=20°C; 1.25 h;
3: With hydrogenchloride; sodium hydroxide
more than 3 stages;
参考文献
Desos, Patrice; Cordi, Alexis; Lestage, Pierre; Danober, Laurence
Patent: US2006/128697 A1, 2006 ;
Location in patent: Page/Page column 7 ;