1-(4-吡啶)-2-丁酮合成路线 （共 5 条）
反应条件
lithium diisopropyl amide
1.) THF, hexane, HMPA, 0 deg C, 30 min, 2.) THF, hexane, HMPA, RT, 90 min; Yield given. Multistep reaction;
参考文献
Robertson, David W.; Beedle, E. E.; Swartzendruber, John K.; Jones, Noel D.; Elzey, T. K.; et al.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 5 p. 635 - 640
反应条件
in ethanol; dichloromethane; sodium carbonate
参考文献
Ippolito; Robert M.; Vigmond; Stephen
Patent: US4681944 A1, 1987 ;
反应条件
diethyl ether; methyllithium
Und weiterem Erwaermen mit Methylpropionat in Aether;
参考文献
Osuch; Levine
Journal of Organic Chemistry, 1957 , vol. 22, p. 939,942
反应条件
2,2'-azo-bisisobutyronitrile; lithium diisopropyl amide
Multistep reaction;
参考文献
Lee, Cheuk Man; Sammes, Michael P.; Katritzky, Alan R.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 2458 - 2462
反应条件
1: 20.4 g / dimethylformamide / 4.5 h / 50 - 65 °C
2: MeONa / dimethylformamide / 2.5 h / 90 - 100 °C
View Scheme
参考文献
Robertson, David W.; Beedle, E. E.; Swartzendruber, John K.; Jones, Noel D.; Elzey, T. K.; et al.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 5 p. 635 - 640
