1-(4-甲氧基苄基)-4-氨基-1H-咪唑-5-羧酸乙酯合成路线 （共 3 条）
反应条件
1: Carbamonitrile; orthoformic acid triethyl ester 2 h; Reflux;
2: 3-N-(p-methoxybenzyl)glycine ethyl ester in diethyl ether
T=20°C; 2 h;
3: With sodium ethanolate in ethanol
T=20°C; 1 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; SIMONEAU, Bruno; DEROY, Patrick; FADER, Lee; FAUCHER, Anne-Marie; GAGNON, Alexandre; GRAND-MAITRE, Chantal; KAWAI, Steven; LANDRY, Serge; MERCIER, Jean-Francois; RANCOURT, Jean
Patent: WO2011/100838 A1, 2011 ;
Location in patent: Page/Page column 55; 56 ;
反应条件
potassium tert-butylate in diethylene glycol dimethyl ether
T=70 - 80°C; 1 h;
参考文献
Zavialov, Ilia A.; Dahanukar, Vilas H.; Nguyen, Hoa; Orr, Cecilia; Andrews, David R.
Organic Letters, 2004 , vol. 6, # 13 p. 2237 - 2240
反应条件
potassium tert-butylate in diethylene glycol dimethyl ether
T=70 - 80°C; 1 h;
参考文献
Zavialov, Ilia A.; Dahanukar, Vilas H.; Nguyen, Hoa; Orr, Cecilia; Andrews, David R.
Organic Letters, 2004 , vol. 6, # 13 p. 2237 - 2240
