1.1: trichlorophosphate / 5 h / |Reflux; |Inert atmosphere 2.1: n-butyllithium / hexane; tetrahydrofuran / 0.75 h / 65 °C / |Inert atmosphere 2.2: 0.75 h / 65 °C / |Inert atmosphere 2.3: 0.5 h / -60 - -40 °C 3.1: diazomethyl-trimethyl-silane / hexane; acetonitrile / 14 h / 0 - 20 °C / |Inert atmosphere 4.1: potassium tert-butylate / dimethyl sulfoxide / 3.5 h / 10 - 20 °C / |Sonication; |Inert atmosphere 5.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / |Inert atmosphere 6.1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C / |Inert atmosphere View Scheme

1.1: triethylamine / benzene / 2 h 1.2: 3.5 h / 90 °C / Reflux 2.1: N-bromosuccinmide / acetonitrile / Reflux 3.1: trichlorophosphate / 5 h / Reflux 3.2: -35 °C / pH 8 4.1: n-butyllithium; tri-isopropoxy-borane / hexane; tetrahydrofuran / 0.75 h / -78 - -65 °C 4.2: 1.17 h / -60 - 20 °C 4.3: 0 °C / pH 6 5.1: diazomethyl-trimethyl-silane / hexane; acetonitrile / 14 h / 0 - 20 °C 6.1: potassium tert-butylate / dimethyl sulfoxide / 10 - 20 °C 7.1: N-ethyl-N,N-diisopropylamine; HATU / 16 h 8.1: hydrogenchloride / water; methanol / 2 h / Reflux 9.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 16 h / 0 - 20 °C View Scheme

1: hydrogenchloride / water; methanol / 2 h / Reflux 2: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 16 h / 0 - 20 °C View Scheme

1: N-ethyl-N,N-diisopropylamine; HATU / 16 h 2: hydrogenchloride / water; methanol / 2 h / Reflux 3: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 16 h / 0 - 20 °C View Scheme