Alpha-氨基-γ-丁内酯氢溴酸盐合成路线 （共 28 条）
反应条件
water; potassium carbonate T=20°C;
参考文献
Vanek, Vaclav; Budesinsky, Milos; Kabeleova, Petra; Sanda, Miloslav; Kozzisek, Milan; Hanclova, Ivona; Mladkova, Jana; Brynda, Jiri; Rosenberg, Ivan; Koutmos, Markos; Garrow, Timothy A.; Jiracek, Jiri
Journal of Medicinal Chemistry, 2009 , vol. 52, # 12 p. 3652 - 3665
反应条件
sodium hydride 2) DMF, 40 - 50 deg C; Yield given. Multistep reaction;
参考文献
Krief, A.; Trabelsi, M.
Synthetic Communications, 1989 , vol. 19, # 7,8 p. 1203 - 1210
反应条件
sodium hydride 2) DMF, 40 - 50 deg C; Yield given. Multistep reaction;
参考文献
Krief, A.; Trabelsi, M.
Synthetic Communications, 1989 , vol. 19, # 7,8 p. 1203 - 1210
参考文献
Mastalerz, Harold; Gavai, Ashvinikumar V.; Fink, Brian; Struzynski, Charles; Tarrant, James; Vite, Gregory D.; Wong, Tai W.; Zhang, Guifen; Vyas, Dolatrai M.
Canadian Journal of Chemistry, 2006 , vol. 84, # 4 p. 528 - 533
反应条件
hydrogen bromide; acetic acid
T=75°C; 4 h;
参考文献
Wolfe, Saul; Wilson, Marie-Claire; Cheng, Ming-Huei; Shustov, Gennady V.; Akuche, Christiana I.
Canadian Journal of Chemistry, 2003 , vol. 81, # 8 p. 937 - 960
参考文献
Yoshitomi Pharmaceutical Industries, Ltd.
Patent: US5948820 A1, 1999 ;
反应条件
1: n-tetradecanoic acid With sodium hydroxide in water
pH=9;
2: α-Amino-γ-Butyrolactone Hydrobromide With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in water
T=20°C; 24 h;
参考文献
Pomini, Armando M.; Cruz, Pedro L. R.; Gai, Claudia; Araujo, Welington L.; Marsaioli, Anita J.
Journal of Natural Products, 2009 , vol. 72, # 12 p. 2125 - 2129
反应条件
acetone
Einleiten von Ammoniak und Erwaermen des Reaktionsgemisches mit Phenylisothiocyanat;
参考文献
Sudo
Nippon Kagaku Zasshi, 1959 , vol. 80, p. 924,933
Chem.Abstr., 1961 , p. 4529
