4-(4-甲氧基-2-甲基-苯基)-丁酸合成路线 （共 11 条）
反应条件
1: aq. HI / Heating 2: ion-exchange resin <H+ form> / Heating View Scheme
参考文献
Hemetsberger,H.
Monatshefte fuer Chemie, 1968 , vol. 99, p. 1225 - 1229
反应条件
hydrogen bromide; acetic acid
参考文献
Sen, P. K.; Pal, Panchanan; Goswami, Shyamaprosad; Chattopadhyay, Gautam
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1987 , vol. 26, p. 679 - 682
反应条件
hydrogenchloride; mercury; zinc
12 h; Heating;
参考文献
Shanker, Sathya P.; Rao, Subba G. S. R.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1995 , vol. 34, # 4 p. 271 - 279
反应条件
1: 75 g / aluminium chloride / nitrobenzene
2: 94 percent / Zn/Hg, concd. HCl / 12 h / Heating
View Scheme
参考文献
Shanker, Sathya P.; Rao, Subba G. S. R.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1995 , vol. 34, # 4 p. 271 - 279
反应条件
potassium hydroxide; sodium hydroxide; hydrazine hydrate
1) diethylene glycol, reflux 2) water, 2h, 100 deg C; Yield given. Multistep reaction;
参考文献
Bhat, K. S.; Rao, A. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, # 4 p. 360 - 364
反应条件
N-bromosuccinmide; meta-chloroperoxybenzoic acid; acetic anhydride; acetic acid
1) CCl4, 1h, reflux, irradiation 2) 1.5h, 115-120 deg C; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Bhat, K. S.; Rao, A. S.
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1983 , vol. 22, # 4 p. 360 - 364
参考文献
Solowewa; Preobrashenskii
Zhurnal Obshchei Khimii, 1960 , vol. 15, p. 60,63
Chem.Abstr., 1946 , p. 1820
反应条件
1: 75 percent / PPA
2: 77 percent
3: 1.) NaBH4; 2.) toluene-p-sulphonic acid / 2.) benzene
4: 92 percent / Pd-C 10percent / xylene / Heating
5: hydrolysis
7: 1.) NH3, Na; 2.) H2 / 2.) Pd-C 10percent / 1.) THF
8: 80 percent
10: trifluoroacetic acid / CH2Cl2 / -20 °C
View Scheme
参考文献
Maity, Sanat K.; Mukherjee, Debabrata
Tetrahedron Letters, 1983 , vol. 24, # 52 p. 5919 - 5920
反应条件
1: 75 percent / PPA
2: 77 percent
3: 1.) NaBH4; 2.) toluene-p-sulphonic acid / 2.) benzene
4: 92 percent / Pd-C 10percent / xylene / Heating
View Scheme
参考文献
Maity, Sanat K.; Mukherjee, Debabrata
Tetrahedron Letters, 1983 , vol. 24, # 52 p. 5919 - 5920
反应条件
1: 75 percent / PPA
2: 77 percent
3: 1.) NaBH4; 2.) toluene-p-sulphonic acid / 2.) benzene
4: 92 percent / Pd-C 10percent / xylene / Heating
5: hydrolysis
View Scheme
参考文献
Maity, Sanat K.; Mukherjee, Debabrata
Tetrahedron Letters, 1983 , vol. 24, # 52 p. 5919 - 5920
