1,2,3-三甲氧基-5-硝基苯合成路线 （共 25 条）
反应条件
1: ethanol With sodium hydride in tetrahydrofuran; N,N-dimethyl-formamide T=20°C; deprotonation; Substitution; 0.666667 h; 2: 1,2,3-trimethoxy-5-nitro-benzene in tetrahydrofuran; N,N-dimethyl-formamide T=20°C; 0.25 h;
参考文献
Wang, Yanong D.; Miller, Karen; Boschelli, Diane H.; Ye, Fei; Wu, Biqi; Floyd; Powell, Dennis W.; Wissner, Allan; Weber, Jennifer M.; Boschelli, Frank
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 21 p. 2477 - 2480
反应条件
1: H2 / Pd-C / ethanol 2: (i) NaNO2, aq. H2SO4, (ii) aq. KI View Scheme
参考文献
Erdtman,H. et al.
Acta Chemica Scandinavica (1947-1973), 1963 , vol. 17, p. 1151 - 1156
反应条件
1: 50 percent / KOH, H2O / 48 h / Heating 2: 68 percent / 18-crown-6 / butan-2-one / 48 h / Heating 3: 64 percent / H2 / 10percent Pd/C / methanol / Ambient temperature View Scheme
参考文献
Topiwala, Upendra P.; Luszniak, Mark C.; Whiting, Donald A.
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 7 p. 1185 - 1191
反应条件
hydrazine hydrate; palladium 10 on activated carbon in ethanol 1 h; Reflux;
参考文献
CENTAURUS BIOPHARMA CO., LTD.; XIAO, Dengming; CHENG, Liang; LIU, Xijie; HU, Yuandong; XU, Xinhe; LIU, Zhihua; ZHANG, Lipeng; WU, Wei; WANG, Shulong; SHEN, Yu; LI, Gen; WANG, Yin; ZHAO, Sheng; LI, Chonglong; TANG, Jia; YU, Honghao
Patent: WO2012/92880 A1, 2012 ;
Location in patent: Page/Page column 60 ;
WO 2012/092880 A1
反应条件
2,2'-azo-bisisobutyronitrile; nitric acid in acetonitrile
T=50°C; nitro-Hunsdiecker reaction; 21 h;
参考文献
Das, Jaya Prakash; Sinha, Pradipta; Roy, Sujit
Organic Letters, 2002 , vol. 4, # 18 p. 3055 - 3058
反应条件
nitronium tetrafluoroborate in ethylene glycol dimethyl ether
T=-50°C;
参考文献
Dwyer; Holzapfel
Tetrahedron, 1998 , vol. 54, # 27 p. 7843 - 7848
反应条件
tert.-butylhydroperoxide; 3 A molecular sieve; zirconium tetra-t-butoxide in dichloromethane
3 h; Ambient temperature;
参考文献
Krohn, Karsten; Kuepke, Jochen; Rieger, Hagen
Advanced Synthesis and Catalysis, 1997 , vol. 339, # 4 p. 335 - 339
反应条件
nitric acid; acetic acid
参考文献
Harding
Journal of the Chemical Society, 1914 , vol. 105, p. 2794
反应条件
1: HNO3, AcOH
3: aq. KOH / methanol
View Scheme
参考文献
Kampouris,E.M.
Journal of the Chemical Society [Section] C: Organic, 1971 , vol. <C>, p. 2577 - 2579
反应条件
2: aq. KOH / methanol
View Scheme
参考文献
Kampouris,E.M.
Journal of the Chemical Society [Section] C: Organic, 1971 , vol. <C>, p. 2577 - 2579
