(3-甲基吡啶-2-基)甲醇合成路线 （共 6 条）
反应条件
sodium hydroxide in methanol T=25°C; 1.5 h;
参考文献
Iqbal, Nadeem; Akula, Murthy R.; Vo, Dean; Matowe, Wandikayi C.; McEwen, Carol-Anne; Wolowyk, Michael W.; Knaus, Edward E.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 11 p. 1827 - 1837
反应条件
1: 81 percent / 1 h / Heating 2: 81 percent / 1 N NaOH / methanol / 1.5 h / 25 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 41, # 11 p. 1827 - 1837
反应条件
1: in dichloromethane T=0 - 45°C; 7 h; 2: With sodium methylate in methanol T=20°C; pH=10; 1 h;
参考文献
EP1431290 A1, ;
Page 22 ;
反应条件
thionyl chloride in dichloromethane T=0 - 20°C; 2.16667 h;
参考文献
PRANA BIOTECHNOLOGY LIMITED
Patent: WO2005/95360 A1, 2005 ;
Location in patent: Page/Page column 58; 59 ;
反应条件
phosphoric acid; dimethyl sulfoxide; dicyclohexyl-carbodiimide T=25°C; 1.5 h;
参考文献
Iqbal, Nadeem; Akula, Murthy R.; Vo, Dean; Matowe, Wandikayi C.; McEwen, Carol-Anne; Wolowyk, Michael W.; Knaus, Edward E.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 11 p. 1827 - 1837
反应条件
thionyl chloride in dichloromethane
T=25°C; 2 h;
参考文献
Weidmann, Klaus; Herling, Andreas W.; Lang, Hans-Jochen; Scheunemann, Karl-Heinz; Rippel, Robert; et al.
Journal of Medicinal Chemistry, 1992 , vol. 35, # 3 p. 438 - 450
