6-甲氧基-2-吡啶甲醇合成路线 （共 13 条）
参考文献
Senomyx, Inc.
Patent: US2009/274632 A1, 2009 ;
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 0.5 h; 2: With water; Potassium sodium tartrate in tetrahydrofuran T=20°C; 1 h;
参考文献
ARRAY BIOPHARMA INC.; BOYS, Mark Laurence; DELISLE, Robert Kirk; HICKEN, Erik James; KENNEDY, April L.; MARESKA, David A.; MARMSATER, Fredrik P.; MUNSON, Mark C.; NEWHOUSE, Brad; RAST, Bryson; RIZZI, James P.; RODRIGUEZ, Martha E.; TOPALOV, George T.; ZHAO, Qian
Patent: WO2012/82689 A1, 2012 ;
Location in patent: Page/Page column 133 ;
WO 2012/082689 A1
反应条件
1: 6-bromo-2-methoxypyridine With n-hexyl lithium in tetrahydrofuran T=-65 - -60°C; 2: N,N-dimethyl-formamide in tetrahydrofuran T=-60°C;
参考文献
WO2011/28395 A1, ;
Page/Page column 20-21 ;
反应条件
sulfuric acid T=95°C; 2 h;
参考文献
Abarca, Belen; Mojarred, Fatemeh; Jones, Gurnos; Phillips, Caroline; NG, Nadine; Wastling, Jonathan
Tetrahedron, 1988 , vol. 44, # 10 p. 3005 - 3014
反应条件
1: 1.) NaH / 2.) 24 h, reflux 2: 80 percent / 2 N sulphuric acid / 2 h / 95 °C View Scheme
参考文献
Tetrahedron, , vol. 44, # 10 p. 3005 - 3014
反应条件
1: 70 percent / dibromotetrachloroethane / toluene 2: 95 percent Spectr. / methanol / 24 h / 60 °C 3: 80 percent / 2N aq.sulfuric acid / 2 h / 95 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 27, # 30 p. 3543 - 3546
反应条件
1.1: silver carbonate / chloroform / 48 h / 60 °C / Darkness 2.1: lithium aluminium tetrahydride / diethyl ether / 4 h 2.2: Molecular sieve View Scheme
反应条件
1: N,N-dimethyl-formamide / 16 h / 20 - 100 °C 2: thionyl chloride / 16 h / 70 °C 3: sodium tetrahydroborate / ethanol / 3 h / 0 - 20 °C View Scheme
参考文献
WO2012/40230 A1, ;
WO 2012/040230 A1
反应条件
1: thionyl chloride / 16 h / 70 °C 2: sodium tetrahydroborate / ethanol / 3 h / 0 - 20 °C View Scheme
参考文献
WO2012/40230 A1, ;
WO 2012/040230 A1
反应条件
thionyl chloride in dichloromethane T=20°C; 16 h;
参考文献
Chuchuryukin, Alexey V.; Chase, Preston A.; Dijkstra, Harm P.; Suijkerbuijk, Bart M. J. M.; Mills, Allison M.; Spek, Anthony L.; Van Klink, Gerard P. M.; Van Koten, Gerard
Advanced Synthesis and Catalysis, 2005 , vol. 347, # 2-3 p. 447 - 462
