2-(4-甲氧基苄基氨基)乙腈合成路线 （共 6 条）
反应条件
lithium diisopropyl amide 1.) THF, -70 deg C, 1 h, 2.) THF, from -70 deg C to RT, 21 h; Yield given. Multistep reaction;
参考文献
Cignarella, G.; Villa, S.; Barlocco, D.
European Journal of Medicinal Chemistry, 1994 , vol. 29, # 1 p. 115 - 120
反应条件
potassium carbonate in acetonitrile
T=60°C; 12 h;
参考文献
Zanobini, Alessandra; Gensini, Martina; Magull, Joerg; Vidovic, Denis; Kozhushkov, Sergei I.; Brandi, Alberto; De Meijere, Armin
European Journal of Organic Chemistry, 2004 , # 20 p. 4158 - 4166
反应条件
triethylamine in tetrahydrofuran
T=20°C; Inert atmosphereCooling with ice;
参考文献
Wallace, Michael B.; Scorah, Nicholas; Vu, Phong H.; Brown, Jason W.; Stafford, Jeffrey A.; Dong, Qing
Tetrahedron Letters, 2010 , vol. 51, # 13 p. 1739 - 1741
反应条件
sodium hydrogensulfite in water
0.25 h;
参考文献
Cignarella, G.; Villa, S.; Barlocco, D.
European Journal of Medicinal Chemistry, 1994 , vol. 29, # 1 p. 115 - 120
反应条件
1: formaldehyd With sodium hydrogensulfite in water
Inert atmosphere;
2: 4-methoxy-benzylamine in methanol; water
T=60°C;
3: sodium cyanide in methanol; water
T=60°C;
参考文献
Mehta, Vaibhav P.; Modha, Sachin G.; Ermolat'Ev, Denis; Van Hecke, Kristof; Van Meervelt, Luc; Van Der Eycken, Erik V.
Australian Journal of Chemistry, 2009 , vol. 62, # 1 p. 27 - 41
反应条件
triethyl amine hydrochloride in chlorobenzene
参考文献
ALMAC DISCOVERY LIMITED; BELL, Mark, Peter; O'DOWD, Colin, Roderick; ROUNTREE, James, Samuel, Shane; TREVITT, Graham, Peter; HARRISON, Timothy; MCFARLAND, Mary, Melissa
Patent: WO2011/55115 A1, 2011 ;
Location in patent: Page/Page column 197 ;
WO 2011/055115 A1
