1,2,3,5,6,7-六氢-S-引达省-4-胺合成路线 （共 8 条）
反应条件
1: With sulfuric acid; nitric acid
T=0 - 5°C; 2 h;
2: With methanesulfonic acid; hydrogen; palladium dihydroxide in methanol; water
P=2585.74 Torr; 9 h;
参考文献
Urban, Frank J.; Jasys, V. John; Raggon, Jeffrey W.; Buzon, Richard A.; Hill, Paul D.; Eggler, James F.; Weaver, John D.
Synthetic Communications, 2003 , vol. 33, # 12 p. 2029 - 2043
反应条件
phosphoric acid
T=160 - 170°C;
参考文献
Vejdelek; Bartosova; Protiva
Collection of Czechoslovak Chemical Communications, 1977 , vol. 42, # 6 p. 1992 - 2000
反应条件
1: HCl, AcOH
2: aq. H2SO4 / ethanol / Heating
View Scheme
参考文献
Birladeanu,L. et al.
Journal of Organic Chemistry, 1977 , vol. 42, # 20 p. 3260 - 3264
反应条件
1.1: 78 percent / AlCl3 / CH2Cl2 / -10 - 20 °C
2.1: H2SO4 / 48 h / 55 - 60 °C
3.1: HNO3; H2SO4 / 2 h / 0 - 5 °C
3.2: 8.8 kg / methanesulfonic acid; H2 / palladium hydroxide on carbon / methanol; H2O / 9 h / 2585.74 Torr
View Scheme
参考文献
Urban, Frank J.; Jasys, V. John; Raggon, Jeffrey W.; Buzon, Richard A.; Hill, Paul D.; Eggler, James F.; Weaver, John D.
Synthetic Communications, 2003 , vol. 33, # 12 p. 2029 - 2043
反应条件
1: 96 percent / 10percent NaOH / H2O / 0.33 h / Heating
2: 99 percent / methanol / 3 h / Heating
3: 1 h / 135 - 145 °C / Heating
View Scheme
参考文献
Vejdelek; Holubek; Bartosova; Protiva
Collection of Czechoslovak Chemical Communications, 1982 , vol. 47, # 12 p. 3297 - 3305
反应条件
T=135 - 145°C; 1 h; Heating; Yield given;
参考文献
Vejdelek; Holubek; Bartosova; Protiva
Collection of Czechoslovak Chemical Communications, 1982 , vol. 47, # 12 p. 3297 - 3305
反应条件
1.1: H2SO4 / 48 h / 55 - 60 °C
2.1: HNO3; H2SO4 / 2 h / 0 - 5 °C
2.2: 8.8 kg / methanesulfonic acid; H2 / palladium hydroxide on carbon / methanol; H2O / 9 h / 2585.74 Torr
View Scheme
参考文献
Urban, Frank J.; Jasys, V. John; Raggon, Jeffrey W.; Buzon, Richard A.; Hill, Paul D.; Eggler, James F.; Weaver, John D.
Synthetic Communications, 2003 , vol. 33, # 12 p. 2029 - 2043
反应条件
1: 99 percent / methanol / 3 h / Heating
2: 1 h / 135 - 145 °C / Heating
View Scheme
参考文献
Vejdelek; Holubek; Bartosova; Protiva
Collection of Czechoslovak Chemical Communications, 1982 , vol. 47, # 12 p. 3297 - 3305
