N-(叔丁氧基羰基)-L-亮氨酸甲酯合成路线 （共 29 条）
反应条件
1: (L)-leucine methyl ester hydrochloride With potassium carbonate in water 1 h; 2: di-tert-butyl dicarbonate With 1-methylguanidine hydrochloride in ethanol T=35 - 40°C; 0.366667 h;
参考文献
Jahani, Fatemeh; Tajbakhsh, Mahmood; Golchoubian, Hamid; Khaksar, Samad
Tetrahedron Letters, 2011 , vol. 52, # 12 p. 1260 - 1264
反应条件
triethylamine in tetrahydrofuran
参考文献
SmithKline Beecham Corporation
Patent: US5998470 A1, 1999 ;
US 5998470 A
反应条件
in dichloromethane T=0 - 20°C;
参考文献
Jones, Raymond C. F.; Bullous, James P.; Law, Carole C. M.; Elsegood, Mark R. J.
Chemical Communications, 2014 , vol. 50, # 13 p. 1588 - 1590
反应条件
4-methyl-morpholine; 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholin-4-ium chloride
参考文献
TOKUYAMA CORPORATION
Patent: EP1178043 A1, 2002 ;
Location in patent: Page 31, 32 ;
反应条件
1: With 4-(N,N-dimethlyamino)pyridine in tetrahydrofuran 4 h; Heating; 2: With hydrazine in tetrahydrofuran; methanol T=20°C; 1 h;
参考文献
Notte, Gregory T.; Sammakia, Tarek
Journal of the American Chemical Society, 2006 , vol. 128, # 13 p. 4230 - 4231
反应条件
sodium carbonate in N,N-dimethyl-formamide T=20°C; Inert atmosphere;
参考文献
Xu, Zhigang; DiCesare, John C.; Baures, Paul W.
Journal of Combinatorial Chemistry, 2010 , vol. 12, # 2 p. 248 - 254
反应条件
triethylsilane; palladium on activated charcoal in methanol 0.5 h;
参考文献
Mandal, Pijus K.; McMurray, John S.
Journal of Organic Chemistry, 2007 , vol. 72, # 17 p. 6599 - 6601
反应条件
1: 95 percent / ethyldiisopropylamine / CH2Cl2 / 4 h 2: 88 percent / triethylsilane / Pd-C / methanol / 0.5 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 72, # 17 p. 6599 - 6601
反应条件
Yield given. Multistep reaction;
参考文献
Tetrahedron Letters, , vol. 33, # 45 p. 6811 - 6814
反应条件
triethylamine in methanol T=25°C; Acylation; 24 h;
参考文献
Journal of Organic Chemistry, , vol. 64, # 23 p. 8468 - 8474
